Sitka Gold, SIG, SITKF, Company Profile, Stock Summary 

Sitka Gold Corp. is a well-funded mineral exploration company headquartered in Canada. The Company is managed by a team of experienced industry professionals and is focused on exploring for economically viable mineral deposits with its primary emphasis on gold, silver and copper mineral properties of merit. Sitka currently has an option to acquire a 100% interest in the RC, Barney Ridge, Clear Creek and OGI properties in the Yukon and the Burro Creek Gold property in Arizona. Sitka owns a 100% interest in its Alpha Gold property in Nevada, its Mahtin Gold property in the Yukon and its Coppermine River project in Nunavut. 
 
Sitka has received all assay results from its 2022 diamond drill program at its RC Gold Project in the Yukon and announced a 43-101 compliant Initial Mineral Resource Estimate of 1,340,000 ounces of gold(1) beginning at surface and grading 0.68 g/t (see news release dated January 19, 2023). A resource expansion diamond drilling program has now begun (March 2023). 

Results from 2022 drilling at the Company’s Alpha Gold Property in Nevada where a new Carlin-type gold system was recently discovered have all been received. The Company is focused on vectoring towards the high-grade core of this newly discovered system, which is located in the Cortez Trend just 40 km southeast of the Cortez Mine Complex of Barrick/Newmont, and plans for a 2023 drilling program at Alpha are currently underway. 

RC GOLD PROJECT 
 
Overview 

Several high priority intrusion related gold targets exist at RC Gold with nine outcropped intrusions identified to date over the 376 sq km property, however Sitka’s main focus at the RC Gold Project has been on the underlying Clear Creek Property where a large 500 metre by 2000 metre intrusion related gold system covering the area over the Blackjack, Saddle and Eiger zones was identified. To date the Company has drilled 38 diamond drill holes into this system for a total of approximately 13,000 metres. This drilling culminated in the discovery of the Blackjack and Eiger deposits with an initial inferred mineral resource estimate of 1,340,000 gold ounces(1). 
 
Sitka Gold inherited a wealth of historical and current data from these properties from work spanning the last 40 years. Recent exploration work and the compilation of historical data have defined several mineralized zones with both bulk tonnage, intrusion-related gold deposit targets and high-grade, vein- and breccia-hosted gold targets. The RC Gold Project also has a common border with Victoria Gold’s Clear Creek property at its western boundary and Florin Resources’ Florin Gold property at its northern boundary. 

The RC Gold Project, comprised of the RC Gold, Mahtin, Clear Creek and Barney Ridge properties, is a district-scale, contiguous land package of 1,891 claims covering approximately 376 square kilometres (37,600 hectares or 92,900 acres) within the geologically fertile and highly prospective Tombstone Gold Belt (TCB) region (Figures 1 & 2). The 1.34 million ounce deposit at the RC Gold Project is an intrusion-related gold deposit similar to other intrusion-related gold deposits that exist throughout the Tombstone Gold Belt such as Victoria Gold’s Eagle and Olive Deposits (with a combined 4.7 million ounces Au) (1), Sabre Gold Mine's Brewery Creek Deposits (1.5 million ounces gold) (2),  Florin Resources Florin Gold Deposit (2.47 million ounces gold) (3) and Banyan Gold's AurMac Project (3.99 million ounces gold) (4). Numerous placer gold deposits also exist throughout this gold-rich belt. The Tombstone Gold Belt is located within the larger Tintina Gold Belt which also hosts Kinross Golds’ Fort Knox deposit in Alaska (3 million ounces of gold) (5) (see Figure 1). Several additional intrusion related gold deposit targets a present across the RC Gold Project but have yet to be tested as the initial focus has been at the Blackjack and Eiger zones. 

Location 

The RC Gold Project is situated about 100 km east of Dawson City, Yukon at the headwaters of Clear Creek and Big Creek, a major placer mining district that is serviced by a network of gravel roads and trails. A new, well maintained placer mine access road traverses through the south side of the claim block and provides great access across the Property (Figure 2). This road connects to the Clear Creek road which connects to the Klondike Highway, approximately mid-way between Stewart Crossing and Dawson (Figure 1). The contiguous RC Gold Project claim block is strategically located within the heart of the Tombstone Gold Belt and is surrounded by junior mining companies, including a common boundary with Victoria Gold to the west and Florin Resources' 2.47 million ounce gold deposit to the north (Figure 2).  Initial Mineral Resource Estimate 

On January 19, 2023 Sitka Gold announced an Initial Mineral Resource Estimate prepared in accordance with National Instrument 43-101 (“NI 43-101”) guidelines for the RC Gold  Property of 1,340,000 ‎ounces of gold. The road accessible, pit constrained Mineral Resource is classified as inferred and is contained in two near/on-surface zones: The Blackjack and Eiger deposits. The Mineral Resource estimate is presented in the following table at a base case cut-off grade of 0.25 g/t Au: 

The Initial Mineral Resource Estimate of 1,340,000 ounces of gold at the RC Gold Project is comprised of two deposits: the Blackjack deposit containing 900,000 ounces of gold at a grade of 0.83 g/t gold and the Eiger deposit containing 440,000 ounces of gold at a grade of 0.50 g/t gold (see news release dated January 19, 2023). Both of these deposits are at/near surface, are potentially open pit minable and amenable to heap leaching, with initial bottle roll tests indicating that the gold is not refractory and has high gold recoveries of up to 94% with minimal NaCN consumption (see News Release July 13, 2022). 
  

The Blackjack and Eiger deposits are in close proximity to highway and power infrastructure, are road accessible year-round, remain open in all directions and are respectively located at the western and eastern end of a large, 500 metre by 2 kilometre intrusion related gold system that was recently discovered on the Property. As of March 1, 2023 just 38 diamond drill holes have been drilled into this system for a total of approximately 13,000 metres with results of up to 201.0 m of 1.26 g/t gold from surface, including 82.0 m of 2.04 g/t gold and 19.5 m of 4.87 g/t gold at Blackjack (drill hole DDRCCC-22-040; see news release dated January 11, 2023) and 354 m of 0.41 g/t gold including 72 m of 0.72 g/t gold at Eiger (drill hole DDRCCC-21-09; see news release date August 19, 2021). 

Project History 
Placer Mining first began on Clear Creek in the late 1800's and the first quartz claims were staked in the early 1900's. Placer mining has continued to the present, with a dredge operating on Clear Creek from 1943 to 1954 and again between 1981 and 1987. Several active placer mines continue to operate in the Clear Creek drainage and new placer mining activity has recently begun in Big Creek. 
 
The first modern hard rock exploration in the area took place in the 1970's, targeting silver, tin and tungsten, metals commonly associated with Intrusion Related Gold deposits. High grade gold-silver and silver-lead-zinc veins have also been prospected. 
 
In the 1990's, exploration shifted to bulk tonnage gold after the discovery of the Fort Knox gold deposit in Alaska, in a similar geological environment. Explorers in and around the vicinity of the RC Gold Project included Noranda, Ivanhoe Goldfields, Kennecott and Newmont. These companies carried out geological mapping, geochemical and geophysical surveys and several campaigns of drilling. More recently, in the 2000s, Thor Exploration, StrataGold, Golden Predator, Pacific Ridge and Kestral Gold have explored on the west side of the RC Project, while Ryan Gold (now StrikePoint) explored to the east. AM Gold’s Red Mountain Property, an intrusion-related gold target that is adjacent to the the Project's northern border, has also seen exploration throughout the 2000’s and has a resource of 1.95 million of gold ounces defined.  
 
RC Gold Property (RC, BEE & BOP Claims) 
In 2017, the RC Gold Property was optioned to Pacific Ridge Exploration Ltd. who completed a program of geological mapping and property-wide soil sampling that same year. Pacific Ridge conducted additional soil sampling, mapping and a small geophysical survey in 2018. These work programs produced encouraging results with several previously unknown gold-in-soil anomalies shown to be present on the Property. In 2019, after acquiring the Property, Sitka Gold followed up on these results with a soil sampling and geophysical survey program designed to expand and fill in the previous geophysical and geochemical anomalous zones that had been identified. Together, this work has defined several high-priority gold targets where the gold values, plus the associated pathfinder metals, are typical of mineralization associated with Intrusion Related Gold deposits. Two of these mineralized zones appear to be contiguous representing an Intrusion Related Gold target that is 2 km long by 0.5 km wide (see Figure 3). In 2020 Sitka completed 2 helicopter supported drill holes in the Big Creek and Far Grid targets and also flew a LiDAR survey across the western half of the Property. 

Geological Setting 
The area of the RC Gold property is underlain by phyllite, quartzite, calc-phyllite, calc-silicate, grit and marble of the Proterozoic to Early Cambrian Hyland Group. These metasedimentary rocks are imbricated by thrust faults of Jurassic and Early Cretaceous age. The Clear Creek area is in the hanging wall of the Robert Service Thrust. 
 
At the headwaters of Clear Creek, six Tombstone-style intrusions with ages of approximately 92 my, include the Saddle, Eiger, Pukelman, Rhosgobel, Josephine and Big Creek stocks. They have surface exposures ranging from 0.2 to 3.5 km2. The Saddle, Pukelman and Rhosgobel stocks are composed of medium- to coarse-grained quartz monzonite The Josephine and Big Creek stocks are composed of fine- to medium-grained, equigranular granodiorite. The Eiger stock is composed of fine to medium-grained, equigranular diorite with rare mafic phenocrysts. 
 
Contact metamorphism of the Hyland Group country rocks extends for as much as 0.5 km around the stocks and typically occurs as resistant, rusty weathering biotite hornfels. 
 
Mineralization 
The RC Gold property lies within the heart of the Tintina Gold Belt. Hart (2005) has estimated a total metal endowment on the order of 70 million ounces of gold. Key deposits include Brewery Creek and the Eagle deposit (Dublin Gulch) in Yukon and Fort Knox, True North, Pogo and Donlin Creek in Alaska. Most of these deposits are characterized by flanking placer gold creeks. 

Photograph of Placer Gold Down-Drainage  

from Hole 21 & Surface Prospecting Area 

 
The immediate area of the RC Gold property is characterized by several styles of mineralization associated with the Tombstone-aged intrusions, but the most important of these is sheeted veins, stockworks and breccias that occur within the intrusions and adjacent hornfels. These veins typically contain minor amounts of sulphide, including arsenopyrite, pyrite and rarely pyrrhotite. Other minerals include scheelite (tungsten), molybdenite, galena, chalcopyrite and bismuthinite. Arsenic, bismuth, tellurium, antimony, tungsten and molybdenum are typical pathfinder elements when prospecting for gold in these types of systems. 

 
Management 

Corwin (Cor) Coe, B.Sc., P.Geo. 
CEO and Director 
 
Cor has over 35 years’ experience in the mining industry working primarily in Arizona, Nevada and the Yukon and has put two mines into production in the past. He is also credited with the discovery of a 2.0 million ounce gold deposit.  
 
Cor is a Professional Geologist, Mining Engineering Technologist and Gemologist, holding a Bachelor of Science degree in Earth Sciences from Simon Fraser University and a Diploma in Mining Engineering Technology from the British Columbia Institute of Technology. He is a member of the Association of Professional Engineers and Geoscientists of British Columbia (APEGBC) and, the Northwest Territories and Nunavut Association of Professional Engineers and Geoscientists (NAPEG). Cor has been a Director and/or Officer of several successful public mining companies and previously was a fully licensed Investment Advisor and branch manager of a national brokerage firm.  
 
Most recently, Cor was the founding CEO and a Director of Tundra Copper Corp., where he led the company from its inception through property acquisition, exploration and the successful sale of the company over an 18 month period. Cor is currently focused on building shareholder value in Sitka Gold Corp. 

Donald Penner, B.Sc. 
President and Director 
 
Mr Penner brings over 40 years of technical and managerial experience in mineral industry.  Mr Penner graduated in 1976 from the University of British Columbia with a Bachelor of Science Degree in Geology.  Throughout his career, he gained extensive experience at all levels of mineral property evaluation from grassroots to feasibility-stage on projects in Canada, United States, Africa, South America and Europe.  During the late 1970’s, Mr. Penner was a key participant in the discovery of several silver/lead deposits in the central Yukon.  His success continued as a member of the exploration team that discovered the Eskay Creek deposit for Prime Resources Ltd in the late 1980’s.  Other world class deposits he worked on include Donlin Creek in Alaska and Galore Creek in northwestern British Columbia for NovaGold Resources Ltd.  Mr. Penner founded his own successful geological consulting practice in 1990 which he operated for 30 years. 
 

Mike Burke, B.Sc., P.Geo. 
Director and VP of Corporate Development 
 
Mike has over 35 years experience in the mining industry primarily in the Yukon. Mike’s career has covered a wide range of experience including 20 years with the Yukon Geological Survey where he was the Head of Mineral Services. Mike was responsible for liaising with prospectors, mining and exploration companies, visiting active exploration sites, authoring the annual Yukon Mining, Development and Exploration Overview and presenting information on Yukon to investment bankers, financial institutions and mining analysts in meetings and conferences around the world. Mike also has experience as an exploration and mine Geologist earlier in his career and was fortunate to be part of the exploration team that discovered the Sa Dena Hes lead-zinc mine and the Ketza River Gold mine in the Yukon. Most recently, Mike was the Chief Geologist for Golden Predator in Yukon and Senior Operations Manager for Ensero Solutions, an environmental and engineering consulting firm. 
 
Mr. Burke holds a BSc in Geology from the University of British Columbia, is a Professional Geologist with the Engineers and Geoscientists of British Columbia and a member of the Society of Economic Geologists. Additionally, Mike is a Director of the Yukon Chamber of Mines (YCM). He has served on the Board of the YCM continuously since 2013 including holding the role of President from 2015-2019. 
 
 

J. Greg Dawson, M.Sc., P.Geo. 
VP Exploration (Canada) and Director 
 
Mr. Dawson has over 30 years of experience in mineral exploration. He holds a B.Sc. in geology from the University of British Columbia, a M.Sc. from Queens University and is a registered Professional Geoscientist with EGBC. His work experience includes acting as Director of Exploration for GroundTruth Exploration, Vice President Exploration for Colorado Resources, President and Vice President, Exploration of Copper Ridge Exploration as well serving as District Manager and General Manager with Teck Exploration Ltd. in Central Asia and South America. He also spent several years earlier in his career working for the Hunter Dickinson Group and its associated companies. 
 

Jodie Gibson, MBA, P.Geo. 
Chief Geologist 
 
Mr. Gibson is a professional geologist with over 15 years mineral exploration experience throughout the North American Cordillera from Alaska to Mexico; including syngenetic and epigenetic precious and base metal systems. He was the Project Manager of the Underworld Resources Inc. exploration team that discovered and defined the Golden Saddle and Arc deposits. These assets were subsequently sold to Kinross in 2010 for $139 million., Mr. Gibson also served as Vice President Exploration for White Gold Corp where he oversaw over $30 million in exploration activities with highlights including expansion of the Golden Saddle and Arc deposits and five new discoveries across the White Gold district; including the high-grade Vertigo discovery on the JP Ross property. In 2020, Mr. Gibson  was recognized as the 2020 Yukon Prospector of the Year. 

Scott Price, B.Sc., M.Sc. 
VP Exploration (USA) 
 
Mr. Price has over 25 years experience with major and junior mining and exploration companies in the U.S and Canada.  Most of his career has focused on gold exploration in Nevada, where he worked on the discovery and definition teams at the Hollister epithermal deposit, and the Phoenix (Battle Mountain district) and Mount Hamilton Carlin-type/intrusion-related gold deposits.  Mr. Price also contributed to discovery of the deep east ore body at the Pebble porphyry Cu-Au deposit in Alaska.  Much of his career involved early stage exploration and prospect assessment in Nevada.  He began a geologic consulting business in 2008, in order to devote more time to his own Nevada research and prospecting.  Mr. Price holds a B.S. degree from the University of Wyoming and a M.S. degree from Washington State University, both in geology. 

About Daily Stock Deals 

Daily Stock Deals helps emerging growth companies reach individual and institutional investors. Daily Stock Deals and its affiliates publish research reports, market analysis and daily stock picks to help investors make informed decisions and achieve their individual investment goals. Our Platform is supported by companies we profile on our network, therefore, our views are neither free of conflict, nor intended as advise to buy/sell any securities and we strongly urge you to read our TOS, Disclaimer/Disclosure and consult with qualified experts. If you would like to get your company featured on Daily Stock Deals network or have any questions, please feel free to contact the editor. This email address is being protected from spambots. You need JavaScript enabled to view it." target="_blank" rel="noreferrer noopener">This email address is being protected from spambots. You need JavaScript enabled to view it." target="_blank" rel="noreferrer noopener">This email address is being protected from spambots. You need JavaScript enabled to view it. thanks! 

Daily Stock Deals is an affiliated/partner property, please read TOS/Disclaimer/Disclosure, thanks! 

Editor, Daily Stock Deals 

For timely, actionable and potentially profitable news and uncensored views:> sign up for FREE in 15 seconds 

Keep an eye on this space for major announcements! 

Reminder: Free Membership enables immediate access to @TOP10STOCKS a great way to start your trading day 

Source: The Company, OxBridge Research, Daily Stock Deals, PennyStockIQ 

Sayona Mining an Emerging Lithium Leader in North America 

Sayona Mining, SYA, SYAXF, Company Profile, Stock Summary 

Sayona is a successful mining company based in Australia with a great history of successfully discovering and developing mines in Australia, the company has been publicly trading on the Australian Stock Exchange for nearly 20 years.  

North American Operations 

The unprecedented financial incentives offered by the American Government was a no brainer for the company’s management to find a beachhead in North America.  

The company has acquired 3 mines in one of the most prolific Lithium Rich regions of Quebec. The company’s success in Quebec speaks for itself! 

Sayona Mining became one of the very few companies to produce Lithium in North America! 

12,000 Tons of Commercial Grade Lithium Ready to Shipped, learn more

See the press release announcing the historic achievement. Click here > 

North American Lithium 

Project Overview 

Sayona’s flagship, the North American Lithium (NAL) operation was acquired by Sayona Québec in August 2021, in partnership with Piedmont Lithium Inc (Sayona 75%; Piedmont 25%). 

Forming the key part of Sayona’s Abitibi hub along with the nearby Authier Lithium Project, the restored NAL operation together with the Company’s emerging northern hub, now comprises North America’s largest lithium (spodumene) resource base. 

NAL comprises 19 contiguous claims covering 582.31 and one mining lease, covering approximately 700 ha. It is situated in La Corne township in Québec’s Abitibi-Témiscamingue region. The project lies 60km north of the city of Val d’Or, a major mining service center, and in proximity to Sayona’s Authier Lithium Project (Authier). 

NAL is a brownfield open pit mining operation with a concentrator, with more than C$400 million having been invested in the operation by previous owners, including a carbonate plant. The existing plant has a nameplate capacity to produce up to 220kt of spodumene concentrate or 30kt LCE per year. 

Sayona plans to combine ore produced from Authier with ore produced at NAL to facilitate a significant improvement in plant performance and economics and transform both operations. 

Importantly, nearly all of NAL’s power is from clean and green hydroelectricity, while it is well serviced by provincial highways and an all-weather secondary road. 

Management & Board 

Mr Brett Lynch 

Managing Director and Chief Executive Officer 

Appointed on 1 July 2019, Brett is a highly experienced international company director and chief executive, with a strong background in mining and mining-related businesses across Australia, Asia and North America and a proven track record in advancing shareholder value. 

A senior mining engineer and manager, he has more than 30 years’ experience in the global industry, including previous posts with leading resources companies such as MIM Holdings, New Hope Corporation, Orica and VLI, during which time he was responsible for multi-million-dollar international operations. 

Brett’s professional qualifications include a Bachelor of Engineering (Mining) (Honours) at the University of Melbourne, a Graduate Diploma of Business (Accounting) at Monash University and a Company Director Diploma from the Australian Institute of Company Directors. 

Mr James Brown 

Non-Executive Director 

James holds formal qualifications in mining engineering with more than 40 years’ experience in the mining industry in Australia, the United States, Africa and Indonesia, including 14 years as Managing Director of ASX-listed Morella Corporation Limited. 

He has successfully sourced, developed and operated numerous key global projects with a focus on lithium and battery minerals. He has an extensive global investment network to underpin the capital requirements for project investment and development. 

He was appointed to the Board on 12 August 2013. He also serves as a Director of Greenwing Resources Limited. 

Mr Paul Crawford 

Executive Director and Chief Financial Officer 

Paul is an accountant with over 40 years of commercial experience in various technical and management roles within the minerals, coal and petroleum industries. He has also had significant corporate experience in the management and governance of ASX-listed resource and mining companies. 

He is the principal of a corporate consultancy firm he established in 2001, offering a range of commercial and corporate governance services to corporate clients. Paul was appointed to the Board on 10 March 2000. 

Mr Allan Buckler 

Non-Executive Director 

A qualified mine manager with more than 40 years coal experience in Australia and Indonesia, Alan joined Sayona’s Board on 5 August 2013. 

He has had key roles in the establishment of several large mining and port operations in both Australia and Indonesia. 

Allan is a former Director and Chief Operations Officer of New Hope Corporation Limited and has led the development of significant operations including PT Adaro Indonesia, PT Indonesia Bulk Terminal and PT Mult Harapan Utama in Indonesia. 

He also serves as a Director of Morella Corporation Limited (previously Altura Mining Limited) and Interra Resources Limited. 

Québec Leadership 

Mr Guy Belleau 

Chief Executive Officer, Sayona Québec 

With more than 30 years’ experience in the mining industry, Guy is an exceptional senior mining executive who has held strategic positions in the largest mining companies in Québec and Canada. 

During his career, he has served as Chief Operating Officer for ArcelorMittal Mines Canada, General Manager of Mining for Falco Resources, and General Manager of Mining for Goldcorp's Eleonore mine. 

An engineer by training, Guy has also chaired the board of directors of the National Institute of Mining since 2018. 

Guy manages Sayona's activities in Abitibi-Témiscamingue, including North American Lithium, the Authier and Tansim projects. 

He has been appointed CEO of Sayona's Québec subsidiary effective 1 January 2023. 

Mr Guy Laliberté 

Strategic Advisor to Sayona Managing Director 

Heading Sayona’s activities in Québec from 2019-22, Guy has more than 35 years’ experience in major mining and metallurgical projects. 

During his career, he has contributed directly to the realization of major mining projects in Sierra Leone, Liberia and Baffin Island, with companies such as SNC-Lavalin, African Minerals and Baffinland Iron Mines. 

A graduate of ETS in Construction Engineering and Management, he uses his leadership to guide Sayona's teams in the realisation and execution of the company's strategy in Québec. 

Guy has been appointed strategic advisor to Sayona's Managing Director, Brett Lynch, effective 1 January 2023. 

Mr Sal Vitale 

Chief Financial Officer, Sayona 

A graduate of McGill and Concordia Universities, Sal has more than 25 years' experience in strategic positions with leading companies. Prior to joining Sayona, Sal Vitale was Vice President Finance at LSSV Capital. Before that, he served as Chief Financial Officer at Alliance Magnesium. 

As CFO, he guided Transforce to multiply its annual revenues to over $1 billion by overseeing over 50 acquisitions. At Intertape Polymer, Sal Vitale helped grow annual revenues from $200 million to $1 billion. 

Sal puts his business building skills to work for Sayona and its ambitions to become a world-class company, a leader in the energy transition of transportation. 

Sylvain Collard 

Executive Vice President & Chief Operating Officer 

Sylvain has been in charge of Sayona's operations in Québec since autumn 2022. He is responsible for the Company’s three projects in Abitibi-Témiscamingue, as well as the Moblan and Lac-Albert projects. 

A specialist in mine project management and continuous process improvement, he has extensive experience in operations management for both open pit and underground mines. 

During his career, Sylvain has worked on several IAMGOLD mining projects, notably as manager of a major capital project at the Essakane mine in Burkina Faso, where 3,500 workers were under his direction. He has also managed copper and gold mines and projects in Québec, Ontario and the United States. 

Ms Cindy Valence 

Executive Vice President & Chief Sustainability Officer 

Cindy has applied her energy and conviction regarding sustainability, societal impact and value co-creation for Sayona since 2021. 

Always on the lookout for best practices from mining companies around the world, she works to build exemplary relationships between the company and the communities where it operates. 

Cindy sits on the Board of Directors of Women in Mining in Abitibi and of Propulsion Québec, the electric and intelligent transportation cluster. She holds an MBA, with a specialization in the mining industry. 

Northwest Biotherapeutics, NWBO, Company Profile, Stock Summary 

Northwest Biotherapeutics, NWBO, is a clinical stage biotechnology company focused on the development of personalized cancer vaccines designed to treat a broad range of solid tumor cancers. 

NW Bio is developing cancer vaccines designed to treat a broad range of solid tumor cancers more effectively than current treatments, and without the side effects of chemotherapy drugs. NW Bio’s proprietary manufacturing technology enables the Company to produce its personalized vaccine in an efficient, cost-effective manner. The Company has a broad platform technology for DCVax dendritic cell-based vaccines. The Company’s lead product, DCVax-L, is currently in a 348-patient Phase III trial for patients with newly diagnosed Glioblastoma multiforme (GBM), the most aggressive and lethal brain cancer. The Company’s second product, DCVax-Direct, is currently in a 60-patient Phase I/II trial for direct injection into all types of inoperable solid tumor cancers. The Company has also conducted a Phase I/II trial with DCVax for late stage ovarian cancer together with the University of Pennsylvania. The Company previously received clearance from the FDA for a 612-patient Phase III trial with its third product, DCVax-Prostate, for late stage prostate cancer. 

Dendritic Cell Immunotherapy 

Development of effective immune therapies for cancer has long been a goal of the medical and scientific communities. The human immune system is very powerful, and also very complex: it is an “army” with many divisions and many different kinds of weapons. Dendritic cells are the “General” of this immune system “army.” They deliver the “marching orders” to the rest of the immune system agents which tell those agents what to attack. 

A diagram of some key agents and weapons of the immune system is set forth below: 

DCVax ® Technology 

DCVax® is a platform technology that uses activated dendritic cells (the master cells of the immune system), and is designed to reinvigorate and educate the immune system to attack cancers. Unlike conventional cancer drugs, which use one active agent to hit one target on the cancer, DCVax uses many active agents to hit many targets on the cancer. 

We believe that at least three key aspects of the DCVax technology contribute to the positive results (described more fully below) seen in clinical trials to date: 

(1) DCVax is designed to mobilize the entire immune system, not just one among the many different categories of immune agents in that overall system. 

As described above, DCVax is comprised of activated, educated dendritic cells, and dendritic cells are the master cells of the immune system, that mobilize or help the entire immune system. Some of the prominent cancer drugs today are composed of just one type of antibody — and antibodies themselves are just one type of agent in the overall immune system “army” (see Diagram 1 above). In contrast, the full immune system involves many types of antibodies, and also many other kinds of agents besides antibodies. Similarly, there have been a variety of early immune therapies that failed in the past. These, too, typically involved single agents, such as a single one among the many, many types of immune signaling molecules (e.g., a particular interferon or interleukin), or a single type of agent such as T cells alone, etc. In contrast, dendritic cells mobilize all of these different categories of agents, comprising the whole immune system “army,” in combination with each other and in their natural relationships to each other. 

(2) DCVax is designed to target not just one but the full set of biomarkers on the patient’s tumor. 

As mentioned above, cancer drugs are typically rifle shots aimed at just one target on a patient’s cancer. However, cancer is a complex and variable disease. Tumor profiles vary among patients with the “same” cancer and also vary as the disease progresses. Further, when rifle shot drugs hit individual targets on cancers, the cancers find ways around them (called “escape variants”) — and the rifle shot treatments then usually stop working. DCVax takes the opposite approach: instead of aiming at a single target, DCVax is designed at to target the full set of biomarkers on a patient’s cancer. Such a treatment approach is expected to make it more difficult for tumors to develop escape variants. 

(3) DCVax is personalized, and targets the particular biomarkers expressed on that patient’s tumor. 

Extensive scientific evidence has shown that there is substantial variation in tumor profiles and characteristics among patients with the “same” cancer. The degree of variation is particularly enormous in some of the most aggressive cancers, such as GBM brain cancer and pancreatic cancer. Cancer drugs are typically keyed to a single target which is believed to be found on the cancer cells’ surface or in one of the cancer cells’ signaling pathways in a substantial percentage of patients with a given type of cancer. Such drugs can be of no use in patients whose cancers do not happen to express that particular target, or cease expressing that target as the disease progresses. Most cancer drugs only achieve clinical benefits in a limited percentage of the patients with the type of cancer being targeted (e.g., 25 – 30% of the patients). In contrast, DCVax has achieved clinical benefits (i.e., longer delay in disease progression and longer extension of survival than with standard of care treatment) in over 80% of the patients who have received DCVax in clinical trials to date. Since DCVax is made with biomarkers from the patient’s own tumor, it is automatically tailored to targets that are present on that patient’s cancer. 

The DCVax technology is expected to be applicable to most cancers, and is embodied in several distinct product lines. One of the product lines (DCVax®-L) is designed to cover all solid tumor cancers in which the tumors can be surgically removed. Another product line (DCVax®-Direct) is designed for all solid tumor cancers which are considered inoperable and cannot be surgically removed. We believe the broad applicability of DCVax to many cancers provides multiple opportunities for commercialization and partnering. 

On November 17, 2022 the Company Published the latest Phase 3 results in JAMA 

Northwest Biotherapeutics Reports Positive Top-Line Results From Phase 3 Trial of DCVax®-L for Glioblastoma 

Both Median Survival and “Long Tail” of Extended Survival Were Increased In Both Newly Diagnosed and Recurrent Glioblastoma 

Results Featured In JAMA Oncology Peer Reviewed Publication 

BETHESDA, Md., November 17, 2022 – Northwest Biotherapeutics (OTCQB: NWBO) (“NW Bio”), a biotechnology company developing DCVax® personalized immune therapies for solid tumor cancers, today reported that in its Phase III clinical trial both median survival and the “long tail” of extended survival were increased in both newly diagnosed and recurrent glioblastoma brain cancer patients treated with DCVax®-L. The trial has met both the primary and the secondary endpoint under the Statistical Analysis Plan for the trial. 

The trial results were reported today in a featured publication co-authored by more than 70 physicians from leading institutions across the U.S., Canada, U.K. and Germany, in the peer reviewed cancer journal JAMA Oncology, entitled “Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination with Extension of Survival Among Patients with Newly Diagnosed and Recurrent Glioblastoma”.  https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 

The Company believes this is the first time in nearly 20 years that a Phase III trial of a systemic treatment has shown such survival extension in newly diagnosed glioblastoma, and the first time in nearly 30 years that a Phase III trial of any type of treatment has shown such survival extension in recurrent glioblastoma. 

Ms. Powers, CEO of NW Bio, commented:  “We are excited to see the meaningful survival extensions in glioblastoma patients treated with DCVax®-L in this trial – particularly in the “long tail” of the survival curve, where we see more than double the survival rates as with existing standard of care. With well over 400 clinical trials for glioblastoma having failed over the last 15 years, it is gratifying to be able to offer new hope to patients who face this devastating disease.” 

Glioblastoma is the most common and most lethal form of primary brain cancer.  Standard of care (SOC) treatments have been virtually unchanged for nearly 20 years.  With SOC treatments, patients typically survive for only about 15-17 months from diagnosis, with the tumor recurring at about 6-8 months from diagnosis and the patients typically surviving for about 7-9 months after recurrence.  Five-year survival from diagnosis is only about 5%. 

About Daily Stock Deals 

Daily Stock Deals helps emerging growth companies reach individual and institutional investors. Daily Stock Deals and its affiliates publish research reports, market analysis and daily stock picks to help investors make informed decisions and achieve their individual investment goals. Our Platform is supported by companies we profile on our network, therefore, our views are neither free of conflict, nor intended as advise to buy/sell any securities and we strongly urge you to read our TOS, Disclaimer/Disclosure and consult with qualified experts. If you would like to get your company featured on Daily Stock Deals network or have any questions, please feel free to contact the editor. This email address is being protected from spambots. You need JavaScript enabled to view it." target="_blank" rel="noreferrer noopener">This email address is being protected from spambots. You need JavaScript enabled to view it." target="_blank" rel="noreferrer noopener">This email address is being protected from spambots. You need JavaScript enabled to view it. thanks! 

Daily Stock Deals is an affiliated/partner property, please read TOS/Disclaimer/Disclosure, thanks! 

Editor, Daily Stock Deals 

For timely, actionable and potentially profitable news and uncensored views:> sign up for FREE in 15 seconds 

Keep an eye on this space for major announcements! 

Reminder: Free Membership enables immediate access to @TOP10STOCKS a great way to start your trading day 

Source: The Company, OxBridge Research, Daily Stock Deals, PennyStockIQ  

Critical Elements Lithium, CRECF, CRE, Company Profile, Stock Summary 

Critical Elements Lithium Corp., OTCQX: CRECF, TSX.V: CRE, FSE: F12, is a Canadian company based in Montreal, Quebec, the company has several high potential mining properties, however, the management is laser focused on developing its largest and most advanced Rose Lithium Project.  

Rose Lithium Project 

Critical Elements can become one of Canada’s largest Lithium producers. Critical Elements is advancing the wholly owned, high purity Rose lithium project in Québec. Rose is the Corporation's first lithium project to be advanced within a land portfolio of over 700 square kilometers. 

The project has received approval from the Federal Minister of Environment and Climate Change on the recommendation of the Joint Assessment Committee, comprised of representatives from the Impact Assessment Agency of Canada and the Cree Nation Government; The Corporation is working to obtain similar approval under the Québec environmental assessment process. 

Location, Location, Location 

Quebec is emerging as the epicenter of Lithium and other Critical Metals, Quebec can become one of the largest suppliers of critical metals to the rapidly expanding Electrical Vehicle market, its proximity to Detroit and the sprawling Battery-Belt makes Quebec an ideal location for large scale mining investment destination. 

Quebec has what it takes to be the leading producer/supplier of Lithium and other Critical Metals – Plentiful, Low-Cost Electricity. Quebec is the Hydro-Electric hub of North America, as the Lowest-Cost Electricity producer for a power-hungry industry that requires a mind-boggling amount of power to extract and refine the metal makes Quebec one of the most economically attractive Lithium producing regions in the world.  

Management 

▪ Jean-Sébastien Lavallée, CEO 
Over 26 years of experience in mining exploration 
Has served as the CEO of Critical Elements Lithium since 2009 

 
The Team includes: 
Former Rockwood Lithium CEO and CFO possess strong lithium development and operational knowledge 

 
▪ Steffen Haber, President 
Former CEO and President of Rockwood Lithium 
Instrumental in the sale of Rockwood to Albemarle for US$6.2 billion in January 2015 

 
▪ Marcus Brune, Director and VP, Finance 
Previously served as CFO of Rockwood Lithium from 2011 up until its acquisition 
Worked in different executive positions in corporate finance and M&A for Rockwood Holdings and its predecessor 
companies since 2004 
Seasoned developers and mine operators with experience in de-risking large-scale projects from the 
point of discovery to production 
 
▪ Yves Perron, VP Engineering, Construction and reliability 
Over 25 years of experience in project management in the industrial sector within major international firms 
Former VP Engineering and Construction for Stornoway Diamond, VP Engineering and Construction for Mason Graphite VP 
Engineering and Construction for Loop Industries 

 
▪ Paul Bonneville, Project Manager 
Over 30 years of operational experience in the Canadian mining industry 
Former VP, Operations of Scorpio Mining and VP, Mines for Cadiscor Resources 

 
▪ Jacqueline Leroux, Environmental Consultant 
Over 20 years of environmental experience in the Canadian mining industry 
Successfully conducted the environmental processes for BlackRock Metals, Mason Graphite and Newmont Goldcorp’s Eléonore 
project 

About Daily Stock Deals 

Daily Stock Deals helps emerging growth companies reach individual and institutional investors. Daily Stock Deals and its affiliates publish research reports, market analysis and daily stock picks to help investors make informed decisions and achieve their individual investment goals. Our Platform is supported by companies we profile on our network, therefore, our views are neither free of conflict, nor intended as advise to buy/sell any securities and we strongly urge you to read our TOS, Disclaimer/Disclosure and consult with qualified experts. If you would like to get your company featured on Daily Stock Deals network or have any questions, please feel free to contact the editor. This email address is being protected from spambots. You need JavaScript enabled to view it." target="_blank" rel="noreferrer noopener">This email address is being protected from spambots. You need JavaScript enabled to view it. thanks! 

Daily Stock Deals is an affiliated/partner property, please read TOS/Disclaimer/Disclosure, thanks! 

Editor, Daily Stock Deals 

For timely, actionable and potentially profitable news and uncensored views:> sign up for FREE in 15 seconds 

Keep an eye on this space for major announcements! 

Reminder: Free Membership enables immediate access to @TOP10STOCKS a great way to start your trading day 

Source: The Company, OxBridge Research, Daily Stock Deals, PennyStockIQ